Note the excessively high morning melatonin level
(31.43). This may
be due to prolonged nocturnal (night) production of melatonin,
and/or late onset of its production. High melatonin
levels may bring about a lack of ovulation in women
as well as decreased body temperature. High melatonin
has been noted in the manic phase of bipolar mood
disorder. Many antidepressant drugs may stimulate
melatonin production, including fluvoxamine (Luvox),
desipramine, and most MAO inhibitors. Prozac may lower
melatonin levels. Because of the disturbance in
melatonin, other hormones such as thyroid, testosterone, and
estrogen can be affected. As well as playing a crucial role in sleep-
wake cycles, melatonin influences other vital functions
including cardiovascular and antioxidant protection,
endocrine function, immune regulation and body
temperature.