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Drugs Used to Control Moderate to Severe Pain

Moderate to Severe Pain
Drug Name Available Over The Counter Uses Mechanism of Action Side Effects - Serious Side Effects - Common Side Effects - Less Common Concerns
Acetaminophen With Codeine Phosphate (Tylenol #3) Yes mild to severe pain acetaminophen interferes with the action of prostaglandins which cause inflammation. Relieves fever, but does not reduce inflammation. Codeine acts on areas in the spinal cord and brain to reduce pain.   dizziness, light headedness, nausea, vomiting, drowsiness, constipation, fatigue gastric pain, allergic reaction, blurred vision, drymouth, headache, nervousness, insomnia loss of appetite physical dependence; decrease dose gradually under medical supervision
Amitriptyline Hydrochloride (Elavil) No relieve major depression and chronic pain affects levels of chemicals (serotonin, norepinephrine, acetylcholine) which are linked to mood, emotion and mental state
 
confusion, heartbeat irregularities, hallucinations, seizures, fatigue or drowsiness, blurred vision, restlessness, trembling, shaking, weakness drowsiness, dizziness, lightheadedness, headache, dry mouth, sensitivity to light, weight gain, nausea heartburn, insomnia, diarrhea, increased sweating, vomiting when stopping the medication, taper over 5-7 days
Butorphenol Tartrate (Stadol)   headache, post-operative pain when narcotic is required blocks impulses at level of spinal cord and brain   headache, sedation, dizziness, insomnia, nasal irritation, confusion, dry mouth, nausea, vomiting, constipation, loss of appetite, unpleasant taste in mouth nervousness, unusual dreams, euphoria, floating sensation, trembling may be habit forming; get up from sitting or lying position slowly, to avoid dizziness
Codeine No mild to moderate pain acts at brain and spinal cord level   dizziness, light headedness, nausea, vomiting, constipation, drowsiness, itching headache, sweating, euphoria may cause physical dependence, with withdrawl symptoms when the medication is discontinued
Drug Name Available Over The Counter Uses Mechanism of Action Side Effects - Serious Side Effects - Common Side Effects - Less Common Concerns
Diclofenac (Cataflam, Voltaren) No mild to moderate pain and inflammation caused by tendinits, arthritis, gout, soft tissue injury interferes with formation of prostaglandins ( cause inflammation and make nerves more sensitive)   nausea, vomiting, heartburn, diarrhea, constipation, headache ulcers or sores in mouth, rashes or blistering of skin, ringing sound in ears, tingling of hands or feet, seizures, blurred vision inhibits blood coagulation, and may increase bleeding at surgery; stop meds well before surgery
Diflunisal (Dolobid) No mild to moderate pain and inflammation caused by tendinitis, arthritis, soft tissue injuries interferes with formation of prostaglandins ( cause inflammation and make nerves more sensitive)   nausea, vomiting, heartburn, diarrhea, constipation, headache ulcers or sores in mouth, rashes or blistering of skin, ringing sound in ears, tingling of hands or feet, seizures, blurred vision inhibits blood coagulation, and may increase bleeding at surgery; stop meds well before surgery
Fentanyl Transdermal (Duragesic) No severe chronic pain a narcotic which acts on spinal cord and brain   dizziness, nausea, vomiting, constipation, drowsiness sweating, skin reaction at patch site, fainting, jerking body movements not recommended for postoperative pain; discontinuing abruptly may cause withdrawl symptoms
hydrocodone bitartrate / acetaminophen (Lorcet, Lortab, Vicodin) No short term relief of acute pain hydrocodone blocks pain at the level of spinal cord and brain; acetaminophen interferes with prostaglandins, which cause inflammation   headache, dizziness, light headedness, nausea, drowsiness, constipation abdominal pain, false sense of well being, depression, loss of appetitite, headache, nervousness, insomnia do not increase doses, even if medication is not working, without consulting your physician
Drug Name Available Over The Counter Uses Mechanism of Action Side Effects - Serious Side Effects - Common Side Effects - Less Common Concerns
Hydrocodone bitartrate / ibuprofen (Vicoprofen) No short term relief of acute pain hydrocodone blocks pain at spinal cord and brain; ibuprofen is a nonsteroidal antiinflammatory medication which interferes with the formation of prostaglandins (cause inflammation and pain)   headache, dizziness, lightheadedness, nausea, upset stomach, drowsiness, constipation abdominal pain, weakenss, insomnia, nervousness, diarrhea, flatulence, dry mouth. discontinue well in advance of surgery, as the medication will prolong bleeding times
Hydromorphone Hydrochloride (Dilaudid) No Severe Pain acts on spinal cord and brain   dizziness, lightheadedness, nausea, vomiting, constipation dry mouth, mood swings, euphoria, nightmares habit forming
Ketorolac Tromethamine Systemic (Toradol) No moderate to severe pain and inflammation, usually post surgery interferes with the action of prostaglandins, which cause inflammation   gastric distress drowsiness, diarrhea, cunfusion, ringing in ears, sensitivity to sunlight, headache do not take with aspirin or other non steroidal antiinflammatory medications
Meperidine Hydrochloride (Demerol) No moderate to severe pain acts on spinal cord and brain   dizziness, lightheadedness, nausea, vomiting, constipation, drowsiness, itching euphoria, flushing of face prolonged use can cause dependence and nerve damage; do not stop abruptly; consult your doctor
Drug Name Available Over The Counter Uses Mechanism of Action Side Effects - Serious Side Effects - Common Side Effects - Less Common Concerns
Methadone Hydrochloride (Dolophine, Methadose) No severe pain; prevent or ease withdrawl symptoms during detoxification long acting opioid which binds with natural opioid receptors throughout central nervous system, altering perception of and emotional response to pain   dizziness, lightheadedness, nausea, vomiting, constipation, itching sweating, swelling of feet and ankles, flushing of face notify your doctor or dentist before any surgery
Morphine (Duramorph, Ms Contin, Roxanol) No severe pain acts on spinal cord and brain   dizziness, lightheadedness, nausea, vomiting, constipation, drowsiness, itching mood swings, euphoria, urinary retention, jerking body movements, hallucinations, sweating notify your doctor or dentist before any surgery
Nalbuphine Hydrochloride (Nubain) No moderate to severe pain acts on brain and spinal cord   dizziness, lightheadedness, nausea, vomiting, constipation, drowsiness, itching euphoria, hallucinations mental or physical dependence
Nortriptyline Hydrochlorice (Pamelor) No major depression, anxiety disorders, panic disorders, chronic pain affects levels of norepinephrine, a chemical within the brain which may be linked to mood, emotions and mental state   drowsiness, dizziness, headache, unpleasant taste, fatigue, weight gain, nausea, increased appetite heartburn, difficulty sleeping, diarrhea, profuse sweating, vomiting should not be within reach of suicidal patients
Drug Name Available Over The Counter Uses Mechanism of Action Side Effects - Serious Side Effects - Common Side Effects - Less Common Concerns
Oxycodone Hydrochloride (Oxycontin) No moderate to severe pain acts on brain and spinal cord   dizziness, lightheadedness, nausea, vomiting, drowsiness, constipation, itching foot swelling, sweating, euphoria, urinary retention tell your doctor or dentist before undergoing surgery
Oxycodone / Acetaminophen (Endocet, Percocet, Roxicet, Tylox) No moderate to severe pain, may produce pain relief better than either oxycodone or acetaminophen used alone oxycodone acts on the brain and spinal cord; acetaminophen interferes with prostaglandins, which cause inflammation and increase sensitivity of nerves   dizziness, lightheadedness, nausea, vomiting, constipation, drowsiness allergic reaction, euphoria, depression, loss of appetite, blurred vision, headache, sweating if medication is not relieving pain, do not increase dose; consult your doctor
Oxycodone / Aspirin (Percodan) No moderate to severe pain; may provide superior relief to either oxycodone (narcotic) or aspirin alone oxycodone is a narcotic and affects the brain and spinal cord; aspirin inhibits prostaglandins, which play a role in inflammation   lightheadedness, dizziness, drowsiness, nausea, vomiting euphoria, depression, constipation, itching prolonged use may lead to abuse through psychological and physical dependence
Pentazocine (Talwin) No moderate to severe pain acts on brain   dizziness, lightheadedness, nausea, vomiting, constipation euphoria, hallucinations, nightmares notify doctor or dentist before surgical procedure
Drug Name Available Over The Counter Uses Mechanism of Action Side Effects - Serious Side Effects - Common Side Effects - Less Common Concerns
Propoxyphene (Darvon) No moderate to severe pain as do other opioids, acts on brain and spinal cord   dizziness, lightheadedness, nausea, vomiting, constipation, itching euphoria, hallucinations notify doctor or dentist before surgery
Propoxyphene / Acetaminophen (Darvocet, Wygesic) No moderate to severe pain propoxyphene acts, as do other opioids, on spinal cord and brain; acetaminophen interferes with prostaglandins, which cause inflammation and make nerves more sensitive   dizziness, lightheadedness, constipation, nausea, vomiting, drowsiness, fatigue gastric pain, euphoria, depression, loss of appetite, blurred vision, nightmares, nervousness, insomnia do not increase your dose if medication not taking effect
Tramadol Hydrochloride (Ultram) No moderate to somewhat severe pain although not a narcotic, works similar to narcotic analgesics, and blocks transmission of pain signals to central nervous system; may be habit forming, with physical and mental dependence   dizziness, vertigo, headache, drowsiness, nausea, vomiting, constipation weakness, lack of energy, anxiety, confusion, insomnia, visual changes, dry mouth, diarrhea, abdominal pain, menopausal symptoms, sweating, muscle spasm, rash notify doctor or dentist before surgery
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