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A laboratory test is a medical procedure that involves testing a sample of
blood, urine, or other tissues or substances in the body. Such tests have
a variety of uses. They are often used as part of a routine checkup to
identify possible changes in a person's health before any symptoms occur.
Laboratory tests also play an important role in diagnosis when a person
has symptoms. In addition, tests may be used to help plan a patient's
treatment, evaluate the response to treatment, or monitor the course of
the disease over time.
Laboratory test samples are analyzed to determine whether the test results
fall within normal ranges. They also may be checked for changes from
previous tests. Normal test values are usually given as a range, rather
than as a specific number, because normal values vary from person to
person. What is normal for one person may not be normal for another
person. Many factors (including the patient's sex, age, race, medical
history and general health) can affect test results. Other factors that
sometimes affect test results include specific foods, drugs the patient is
taking, how closely the patient follows preparatory instructions, and
variations in laboratory techniques. It also is common for normal ranges
to vary somewhat from laboratory to laboratory.
Some
laboratory tests are precise, reliable indicators of specific health
problems, while others provide more general information that simply gives
doctors clues to possible health problems. Information obtained from
laboratory tests may help doctors decide whether other tests or procedures
are needed to make a diagnosis or to develop or revise a previously
diagnosed patient's treatment plan. All laboratory test results must be
interpreted in the context of the overall health of the patient and are
generally used along with other exams or tests. The doctor who is familiar
with the patient's medical history and current condition is in the best
position to interpret that person's test results and explain their
implications. Patients are encouraged to discuss questions or concerns
about laboratory test results with the doctor.
The following are some of the more common blood tests that are performed:
Complete blood count (CBC): A drop of blood
contains a number of different cell types, including red blood cells
(erythrocytes), macrophages, neutrophils, basophils, eoisinophils, B
lymphocytes, and T lymphocytes, among others. Differences in the number or
appearance of any of these cell populations might serve as an indication
of some underlying illness. The list of possibilities is far too long to
delineate here.
Erythrocyte sedimentation rate (ESR): This measure indicates the
rate at which red blood cells settle out in a tube. An increased rate of
sedimentation can serve as sort of general indicator of inflammation in
the body.
Alanine aminotransferase (ALT): The
activity of this enzyme is measured in blood plasma. Elevated levels of
this enzyme can be an indication of viral hepatitis and other forms of
liver disease.
Total protein: Measurement of the total
protein concentration in plasma. Elevated concentrations reflect
dehydration, which might be attributable to vomiting, diarrhea, Addison's
disease, diabetic acidosis, and other conditions.
Albumin: Albumin is the most abundant protein found in blood
plasma, representing 40 to 60% of the total protein. Reduced levels of
albumin may reflect a variety of conditions, including primary liver
disease, increased breakdown of macromolecules resulting from tissue
damage or inflammation, malabsorption syndromes, malnutrition, and renal
diseases.
Globulin: Globulins are a diverse group of
proteins in the blood, and together represent the second most common
proteins (after albumin) in the bloodstream. An elevation in the level of
serum globulin can indicate the presence of cirrhosis of the liver.
Alkaline phosphatase (ALP): Alkaline phosphatases are a family of
enzymes that are present throughout the body. Elevated levels of ALP are
associated with liver and bile duct disorders, and bone diseases.
Calcium: Increased levels of plasma calcium
may indicate the presence of malignant disease or hyperparathyroidism.
Less commonly, it could reflect thyrotoxicosis, vitamin D intoxication,
the use of thiazide diuretics, sarcoidosis, and other disorders. Reduced
levels of calcium may reflect vitamin D deficiency, renal disease,
hypoparathyroidism, magnesium deficiency and other disorders.
Phosphorus: Increased levels of plasma
phosphate ion may indicate imminent renal failure, hypoparathyroidism,
acromegaly, excessive phosphate intake, and vitamin D intoxication.
Sharply decreased levels of plasma phosphate may reflect vitamin D
deficiency, primary hyperparathyroidism, magnesium deficiency, and
diabetic ketoacidosis.
Glucose: Elevated blood glucose levels may
be an indication of diabetes mellitus. Lower-than-normal blood glucose
levels (hypoglycemia) can be caused in a variety of ways, often
transiently, and must be examined under specific clinical conditions
before relating this finding to any clinical disorders.
Blood urea nitrogen (BUN): Various renal diseases can lead to an increase
in the concentration of urea in blood plasma.
Electrolytes: This test measures the levels
of charged ions dissolved in the blood and urine, including sodium,
potassium, calcium, magnesium, chloride, bicarbonate, phosphate, sulfate,
and lactate. Virtually all the metabolic processes in the body are
dependent on the presence of these charged ions, the concentrations of
which are tightly controlled. Deviations from normal levels of each of
these cautions can reflect a wide variety of clinical problems, too
numerous to detail here.
Creatinine: Elevated levels of plasma creatinine may indicate
impaired renal function.
Thyroid stimulating hormone (TSH): This is a test of thyroid
function. Higher-than-normal levels of TSH may indicate hypothyroidism and
lower-than-normal levels may suggest hyperthyroidism. In rare instances,
elevated TSH levels may be caused by pituitary tumors. This test is
fraught with errors, however. Read about a more accurate way to diagnose
hypothyrodism here.
Urinalysis: Urine may be examined for a variety of diagnostic
indicators, including amylase, bilirubin, creatinine, sugars, g-glutamyl
transferase, hemoglobin, lactate dehydrogenase, osmolality, electrolytes,
myoglobin, protein, urea, and many more. Elevated amylase levels can
indicate pancreatic disease; increased urine bilirubin levels signal liver
damage or disease; high serum g-glutamyl transferase suggests biliary
obstruction, cholangitis, cholecyctitis and alcoholic cirrhosis; increased
lactate dehydrogenase in urine is associated with glomerulonephritis,
systemic lupus erythematosus, diabetic nephrosclerosis, and bladder and
kidney malignancies; and so forth.
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