Asthma - The Condition
by Dr. Gary Farr on 13 February 2002

What is it?/Characteristics/Cause

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Inside an Asthma Attack

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See what happens when an asthma attack makes every breath a frightening chore.

 

Asthma is a narrowing of airways in the lungs that causes coughing, wheezing and gasping for breath. It has probably been around since cave dwellers slept on furs coated with dust mites and cockroach crud. But why is it on a rampage today when, ironically, we know more than ever about its causes and treatment? "It's a paradox," says N. Franklin Adkinson, professor of medicine at the Johns Hopkins Medical Institutions. "After over a decade of spending large amounts of money investigating this disease, and finding more powerful, less toxic drugs, all of which should benefit patients, the prevalence has doubled" and the death rate has soared. Consider the 300 million air sacs in the human lungs: Small, fragile, exquisitely designed, they are a critical place where body meets world. The goal, naturally, is to exchange gases: Oxygen from incoming air is transferred to the bloodstream.

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The Inside Aspects of Asthma

 

The passage lining swells. More mucus is secreted. Muscles around the airway tighten Combined, this narrowing makes breathing, particularly exhaling, more difficult. In more severe attacks, wheezing and whistling are heard. To the asthmatic, it can feel like breathing through a straw.

 

Asthma is definitely not a do-it-yourself illness. Nor is it something that should be treated only in emergency rooms. If you suspect you have asthma, don't call The Why Files. Call your doc.

In a normal bronchial tube, relaxed muscles and thin walls allow good airflow. In an inflamed tube, tightened muscles, thickened walls, and abundant mucus inhibit air flow. And carbon dioxide and other waste gases in the blood leave with the exhaled air. This gas exchange is the kind of thing you take for granted until it goes bad. In asthma, that deterioration starts when the lung becomes what doctors call "hyper-reactive." Essentially, that means the airways respond too strongly to a stimulus by narrowing. Breathing becomes more difficult; in severe cases, it becomes impossible, and the disease claims another victim.

Typically, asthma occurs in episodes. The sequence starts with an inflammation, often caused by an allergic response to dust mites, animal dandruff, mold or pollen. That inflammation sets the stage for further irritation. "If your airway is provoked by an allergen, then any other allergen will have a greater effect," says Norman Edelman, a lung specialist who is a consultant to the American Lung Association and dean of the Medical School at State University of New York at Stony Brook.

How bad is asthma?

Asthma - Statistics

 

The passage lining swells. More mucus is secreted. Muscles around the airway tighten Combined, this narrowing makes breathing, particularly exhaling, more difficult. In more severe attacks, wheezing and whistling are heard. To the asthmatic, it can feel like breathing through a straw.

Bad and getting worse. Don't believe us? Then check these numbers:

Doctor and hospital visits due to asthma are up 50 percent in a decade to 14 million per year. That included 1.6 million visits to emergency rooms, the doctor-of-last-resort to many people without health insurance.

Worldwide, the prevalence of asthma ranges from 1.9 percent to 36.7 percent in various countries, according to the International Study of Asthma and Allergy in Children.
 

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What's behind the radical rise in this disease?

Too many causes, too much disease

In their search for the causes of asthma, scientists have blamed lots of disgusting stuff, like roach parts and mite scats. They've also found a few asthma triggers that aren't so disgusting, like cold, dry air.

And even a few that should be healthy, like exercise.

Many, indeed most, cases of asthma, particularly among children, have allergies as a major component. Allergies to what? Dust mites, pollen, animal dander (shed skin), cockroaches, and
certain foods. Different people have different allergies, obviously. Intriguingly, an allergen that sets off a sneezing fit may or may not set off an asthma attack -- even in the same person.

Let's stick with this el-grosso train of thought by looking at some of the more revolting asthma triggers.

Disgusting:

Are all asthma triggers so disgusting?

Not so disgusting

Here's more detail on these triggers -- revolting and otherwise.

An industrial disease?

To some experts, this laundry list of triggers point to the general condition of living in an industrial society as the overarching cause of asthma. "We live in houses that are closed, work in businesses that are closed, the windows don't open, and any pollutant is recirculated," says Cohen. "There's a tremendous amount of volatile organic compounds from synthetic carpet and vinyl upholstery that are off-gassing all the time. Almost everything is carpeted, and that's a place for dust mites to multiply." And many energy-efficient houses have moisture problems that promote the growth of mold and mites. "There are a lot of things going on," Cohen concludes.

Edelman agrees that indoor air pollution is a factor, pointing out that people are spending more time inside. There are dust mites, smoke and mold in houses that are closed for energy efficiency. And kids are spending more time in day care, and are getting more viral infections, which predispose them to asthma."

Outdoor air pollution is also an important cause of asthma, he says, "but it's hard to attribute the increase to that, since it's not been increasing for the last 10 years. At the same time, he adds, the Lung Association says the relationship between asthma and air pollution -- particularly fine particles and ground-level ozone -- is clear enough to require federal passage of the proposed air pollution standards. Air that meets the current EPA standards "precipitate asthma attacks," he states.

Deadly statistics

With each 10 microgram increase in airborne fine particles, reports of asthma attacks go up by 3 percent, according to Douglas Dockery of the Harvard School of Public Health.

Overall death and hospitalization rates rise in lockstep with air pollution levels. For example, an increase in airborne fine particles of 100 micrograms per cubic meter increased the death rate by 13 percent in Sao Paolo, Brazil (see "Air Pollution and Mortality..." in the bibliography). Breathing nitrogen oxide, a key component in auto exhaust, exacerbates the lung's allergic reaction to dust mites. The Why Files covered the air pollution standards dispute.

So exactly what is causing the increase in asthma? "The honest answer is that we don't know" the full story, Edelman concludes. "Speaking for the American Lung Association, I'd say it's urgent that we find out what the true cause is."

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Symptoms/Medical Dx/Medical Tx

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The symptoms of asthma vary among people and can include wheezing, shortness of breath and tightness of the chest. Other asthma symptoms can include: trouble controlling a cough; a persistent cough at night; difficulty breathing during, or soon after, physical exertion or exercise; or waking up at night because of one or more of these symptoms.

Episodes of asthma symptoms (also called asthma attacks, flare-ups or exacerbations) occur when airways narrow, making it difficult - sometimes impossible - to breathe.

Warning signs of an impending asthma attack may include chest tightness, light wheezing, coughing, restlessness when trying to sleep, irritability, itchy throat and watery eyes.

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Diagnosis of allergies begins with a history and physical exam. The person may report symptoms after a specific exposure, such as being around cats.

Sometimes, the individual will have symptoms during particular seasons. For those with ongoing symptoms such as nasal stuffiness, other tests can be performed. The healthcare provider may order a test that looks for eosinophils in the nasal mucus. Allergy testing may be done to determine the particular triggers that cause the individual's symptoms.

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Right or wrong: Do We Know All We Need to Control Asthma?

Always treatable, not curable

If you know what triggers allergic asthma, the obvious strategy is to reduce exposure to those allergens. To pinpoint what causes hyper-reactivity in the lung in allergic asthma, allergists use skin tests, then suggest that the patient reduce or eliminate contact with the allergens. Vacuum the floor. Rip up the carpet. Jettison dusty crud. Nuke the roaches.

This is almost starting to sound like fun, until you remember that pet cats are a potent cause of allergies. Bummer. Ciao, Gato.

Double bummer: The sad part is that these measures doesn't always control allergic asthma. Some dust mites will plague the cleanest houses, and roach control can be problematic -- to say the least -- in poor neighborhoods.

And even good allergen control still leaves patients with symptoms. That disturbing news came from a recent test of immune therapy for allergic asthmatics. In fact, the study contained a double whammy. The goal was to to control allergic asthma with the same kind of allergy shots that relieve sneezing and itching allergies. (Allergies are essentially an overreaction of the immune system to foreign proteins, and these tiny doses of allergens were supposed to "teach" the immune system to tolerate the allergen.)

Although such "immunotherapy" has been used for years in asthmatics, the recent study of 121 children with severe asthma found that it just did not work: Allergy shots reduced neither the number of emergency-room visits nor the need for medication.

Unexpected

The results were a bit of a shock, says lead researcher N. Franklin Adkinson, professor of medicine at the Johns Hopkins Medical Institutions.

"We were surprised at the unequivocal, across-the-board finding, that we could not find any aspect of asthma care that was influenced." Adkinson's allergist colleagues quickly responded that the study did not reflect the real world. For one thing, patients actually evicted their pets, which many patients refuse to do.

For another, the patients saw their doctors every two or three weeks, while most patients are lucky to see their asthma doctors twice a year. Finally, the "astounding 90 percent compliance rate" among patients did not reflect clinical reality. That's according to Michael Kaliner, who spoke to The Lancet (2/8/97) on behalf of the American Academy of Allergy, Asthma and Immunology.

Adkinson admits that the subject population was inevitably tilted toward patients who would obey the rules for the required two to three years. And he adds that while immunotherapy did not help the severe cases who he'd hoped would benefit, there were indications that it might help milder cases, and/or patients with more recent diagnoses.

Norman Edelman, a consultant to the American Lung Association, says the study should be seen in context. "If allergy shots were dramatically successful, we'd know it by now. And if they didn't work at all, we'd know that by now too. So it may work in some selected cases."

As we mentioned previously, there's another lesson in the results: a missing piece of the asthma picture. These patients cleaned out their environments, they saw their doctors, they took their meds, and they still had symptoms. Why? Probably, Adkinson says, "due to an unknown or complicating factor."

There are any number of candidates for unknown asthma factors, but the one that intrigued The Why Files is the personal history of infection. In a recent Japanese study of 867 children, asthma symptoms correlated with reactions to tuberculosis skin tests.

A positive skin test signals "exposure" to TB, meaning the person has either had the disease or been vaccinated against it. The study found that asthma symptoms were one-half to one-third as common among those who were exposed to TB as those who had not been exposed. That indicates, but does not prove, that having TB, or getting the vaccination, somehow protects against allergic asthma.

Enough speculation. What's new on the asthma drug front?

Hot airways, tight airways

Twenty-five years ago, asthma was treated as an acute disease, with drugs designed to dilate, or enlarge, the bronchial tubes that carry air inside the lung. But the biggest advance in recent years stems from the recognition that inflammation -- the process that prepares tissue to combat foreign bodies -- plays a crucial role in the disease, because it sets up the lungs for acute attacks.

With the knowledge that asthma is a chronic, inflammatory disease, doctors have begun to rely on drugs that calm the inflammation and reduce the excess reactivity of the airways.

The most common of these drugs are inhaled versions of corticosteroids -- synthetic hormones that are unrelated to the anabolic steroids used by body builders. The inhaled drugs ensure  that more of the active ingredient reaches the lungs -- although as much as 80 percent of the dose does get ingested through the stomach.

How effective are inhaled corticosteroids? In the March 19, 1997 issue of JAMA (the Journal of the American Medical Association), James Donohue of Brigham and Women's Hospital in Boston reported that patients with moderate to severe asthma who took them had half as many hospitalizations for asthma as other patients. But does lack of hospitalizations mean asthma is effectively treated? I think not.

New federal guidelines on asthma treatment emphasize using steroid drugs to calm inflammation and halt the asthma process at the beginning.

In 1997, U.S. asthma doctors gained access to a new category of drugs that affect an inflammatory mechanism involving molecules called leukotrienes. Two so-called leukotriene inhibitors have recently been approved, and several more are close to approval.

At first, the new drugs will be used when existing anti-inflammatories don't work, says Marcus Cohen, an allergist in Madison, Wis. "We have to see where they fit in; we don't know yet what population they'll best affect." In the future, he says, other inflammatory mechanisms that have already been identified will also become targets for drug therapy.

Furthermore, a series of experimental drugs are about to enter clinical trials. These drugs also exploit a new understanding of how the inflammation actually begins. Two drug companies are looking at antibodies -- think of them as neutralizing agents -- to interleukin-5, a messenger molecule in the inflammatory process. Tests with animals have shown that the antibodies prevent interleukin-5 from activating eosinophils -- immune cells that play a major role in inflammation. Clinical trials are imminent.

Breathing lessons

But better drugs and better patient advice are not enough -- patients obviously need access to them. Part of the problem is cost. Inner-city asthmatics who have poor access to health care tend to rely on emergency rooms where the necessary follow-up is problematic at best. In other cases, patients don't want to fix what doesn't seem broke: They don't see a reason to take preventative medicine on days when they have no symptoms, not understanding that inhaled steroids are a long-term treatment for the inflammation that causes most asthma.

Norman Edelman, of the American Lung Association, sees the issue of patient education as "both a problem and an opportunity. Asthma is an illness where the active cooperation by the patient is critically important -- it leads to better control. You send the patient home with instructions on what to watch for, how to change medicines, about the triggers, how to deal with school, work and home environments. It's a complicated illness, and it requires a lot of patient know-how and activism."

{find_doctor} Locate a practitioner to find the cause of your asthma.
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CRA Dx/Nutritional Tx

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The following reflexes should be tested for the cause and treated accordingly:

These reflexes should be tested and treated with the proper supplementation.

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You may also locate a {find_doctor} competent health care practitioner for testing.

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The following supplements are indicated:

Children 0-5 years: follow the following supplementation per day for 12 weeks to 1 year:

Children 6-12 years: follow the following supplementation per day for 12 weeks to 1 year:

Adults: follow the following supplementation per day for 12 weeks to 1 year:

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Diet/Chiropractic Tx/Exercise & Prevention

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The asthma epidemic among children may have been triggered by youngsters not eating their greens. Increasing affluence has led to many consuming a diet that has more processed food than fresh vegetables.

Now researchers claim that a lack of key vitamins and minerals in the diet may be responsible for the rising levels of asthma in Britain and other Western countries.

In Britain a million children have the condition which is more common among youngsters here than almost anywhere else in the world, affecting up to one in three teenagers.

The scientists studied communities in Saudi Arabia where there are striking differences in lifestyle and the rate of allergies across the country.

More than 100 children aged around 12 with asthma symptoms, who lived in the city of Jeddah and several villages, were compared with 200 non-asthmatic children.

Diet was significantly linked to wheeziness in the children with asthma. Those children with most symptoms had the lowest intakes of vegetables, milk and fibre, vitamin E, calcium, magnesium, sodium and potassium.

Children whose diets were relatively low in vegetables and vitamin E intake were around three times more likely to wheeze.

The researchers, from Aberdeen University and King Abdulaziz University in Jeddah, said the Saudi diet was traditionally based on Arabic foods that bore little resemblance to the Western diet.

'However, with increasing prosperity and commercial exposure, there has been an influx over some three decades of Western-type frozen and prepared foods in supermarkets and restaurants,' they added.

In recent years experts have claimed that the explosion in asthma has happened because children's lives are 'too clean'. They say previous generations were exposed to more dirt - and the microorganisms in it - which helped their immune systems develop resistance to allergies and related conditions.

But the researchers said there was no link between numbers of infections children suffered and levels of wheeziness.

Dr Martyn Partridge, chief medical adviser to the National Asthma Campaign, said: 'This study is consistent with others that suggest that taking fresh fruit and a balanced diet protects against asthma and some other lung diseases. 'It is yet another pointer towards lifestyle as the cause of the increase in prevalence of asthma.'

Dr Neil Barnes, a specialist at the London Chest Hospital, said there was stronger evidence for infections rather than diet being responsible for rising asthma levels. 'But it may turn out that different factors are responsible in different communities,' he added.

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A study published in the November / December 2000 issue of Today's Chiropractic gives some insight into the use of chiropractic in combating asthma. Forty seven patients were observed for a two year period. They had been medically diagnosed with persistent asthma ranging from mild persistent in 11 cases, moderate persistent in 28 cases, to severe persistent in 8 cases. The care rendered consisted of specific {chiro_adj} chiropractic adjustments. The range of visits was from 14 to 44, with the average being 26 during the study period.

All 47 of the study patients showed "a marked improvement ranging from 87 to 100 percent." Their symptoms improved as well as a decrease in their usage of acute asthma attack medication. Even more impressive was the fact that all of the patients in the study reported maintaining their improvement after a two-year follow up.

Childhood Asthma and Chiropractic

Chiropractors suggest that there is a strong link between people who suffer from childhood asthma and nerve interference from subluxation. {chiro_subl} Subluxations are when bones in the spine pressure or irritate nerves causing abnormal nerve function.

An article published in the Journal of Vertebral Subluxation Research (Vol. 1 No. 4) showed positive effects of chiropractic care on 81 children with asthma. It concluded that "Based upon information currently available, chiropractic care represents a safe non-pharmacological health care approach, that may be associated with a decrease in asthma-related impairment, reduced respiratory effort, and a decrease incidence of asthma attacks. The correction of vertebral subluxation could reduce or eliminate the need for medication, and potentially ease the severity of the asthmatic condition."

This was verified in another study. In a study conducted in 1996 by the Michigan Chiropractic Council (MCC), a panel of doctors performed an out-come assessment study to test the qualitative and quantitative effectiveness of chiropractic care on children with asthma. There was an overwhelming interest in the study. More than 500 parents called the MCC seeking to get their child involved in the chiropractic study.

The study, which took place during May and June of 1996, examined the chiropractic effectiveness in correcting the cause of asthma in patients from birth to age 17. The average age of the participant was 10 years. After 30 days of chiropractic health care, patients averaged only one attack, whereas prior to the study they were experiencing more than four attacks. Medications were decreased by nearly 70 percent. Patient satisfaction was rated 8.5 on a scale of 10. More than 70 chiropractors from 62 cities in Michigan participated in the study involving more than 80 children suffering from asthma.

The International Chiropractic Pediatric Association cites several studies when coming to the following conclusion discussing the benefits of chiropractic for children with asthma:

76.5% of patients with bronchial asthma said they benefited from chiropractic treatment. Peak flow rate and vital capacity increased after the third treatment. Significantly lower quality of life impairment rating scores were reported for 90.1% of children after 60 days of chiropractic care. During this same time period the average number of asthma attacks decreased an average of 44.9%, and asthma medication usage was decreased an average of 66.5%. Among parents of asthmatic children who had received chiropractic treatment, 92% considered this treatment beneficial.

Go here for additional information regarding chiropractic treatment.

There are several facts to be realized about asthma and exercise.

Exercise-Induced Bronchospasm (EIB)

Definition: a temporary narrowing of the airways, or bronchospasm, which is induced by strenuous exercise.

Most children with asthma have acute asthma episodes from time to time. These episodes vary greatly in how quickly they start, how severe they are, and how long they last. Episodes brought on by allergens or by exercise develop quickly, whereas episodes caused by viral infections (colds) usually begin slowly over a few days. Severe asthma episodes can be life threatening.

Children's airways are small to begin with, and therefore any changes in the airways can cause significant symptoms in a child. These changes (airway inflammation and bronchoconstriction) cause any combination of four major signs and symptoms:

Each child's asthma is different, meaning that different factors may be responsible for provoking the asthma.

Exercise may cause airways to tighten.

Mechanism of Exercise-Induced Bronchospasm

vigorous exercise

increased oxygen demand

increased breathing rate

airway cooling and drying

EIB is a very common symptom for persons with asthma. Eighty to ninety percent of asthmatics have difficulty breathing with vigorous exercise.

There are a number of people who have not been diagnosed with asthma and who develop breathing problems with vigorous exercise. For example, 50% of people with hay fever or allergic rhinitis (allergic runny nose) and 10% of normal athletes have been found to develop EIB. As these individuals have hyperresponsive airways, a diagnosis of asthma is probable. For this reason it is preferable to refer to breathing difficulties that develop with vigorous exercise as exercise-induced bronchospasm rather than exercise-induced asthma.

Why does exercise create breathing difficulty? There is no simple answer to explain why EIB develops. There has been much debate and controversy over this the past few years. People with asthma begin with hypersensitive airways (or twitchy airways). When exposed to certain stimuli, these airways react by contracting or tightening. When we exercise vigorously, we tend to breathe in and out of our mouth, and our breathing becomes deeper and quicker. The EIB is most likely due to:

  1. cooling of the airways

  2. drying of the airways or loss of water from the airways

  3. involvement of the nervous system; there is promising evidence that chiropractic care can normalize messages sent to the lungs so that bronchspasm can be controled. see the section above on chiropractic

Breathing warm, humidified air (i.e. during swimming) can completely or partially prevent EIB. Breathing cold, dry air seems to make EIB symptoms worse for many people. People who suffer from asthma have certain cells called mast cells in their large bronchi and lungs. The cooling and drying of the airways stimulate the mast cells to produce a chemical substance called a mediator, which causes spasms of the muscles surrounding the airways.

Symptoms of EIB

Obvious Symptoms

With some children, the signs of EIB are very obvious:

For example, these children are generally identified as having asthma in your class; they take medications regularly and they generally have symptoms with other stimuli in addition to exercise.

Subtle Symptoms

There is another group of children who exhibit more subtle signs:

EIB is often overlooked by parents, physicians, teachers, and even the children themselves; if not properly diagnosed, appropriate management is not possible. The child continues to have symptoms and soon learns to limit his or her exercise so that these symptoms or uncomfortable sensations are avoided.

Ways to Reduce EIB

1. Avoid Exercise if Symptoms are Present Prior to Exercise

2. Supplementation

The following supplements are indicated:

Children 0-5 years: follow the following supplementation per day for 12 weeks to 1 year:

Children 6-12 years: follow the following supplementation per day for 12 weeks to 1 year:

Adults: follow the following supplementation per day for 12 weeks to 1 year:

3. Adequate Warm-Up

a period of submaximal exercise before exertion is encouraged i.e. walking and other low level activities, and flexibility exercises should be done; this can be followed by running rapidly on the spot for 30 seconds, followed by a 60 second rest; repeat this 2 or 3 times

4. Modified Exercise

There is no such thing as the perfect exercise for people with EIB. The key is to select a sport or exercise the child enjoys and feels good about doing. Very light or nonaerobic exercise (such as walking or weight training) rarely results in EIB. Exercise intensity should begin at low levels and gradually increase as the child's fitness level improves. Running tends to produce symptoms more easily than do bicycling or walking. Indoor swimming very rarely causes EIB because it is performed in a humid and often warm environment; it is a sport often chosen by people with asthma.

Other sports relatively well tolerated include:

5. Avoid Environmental Factors

are known to aggravate EIB. People with inhaled allergies may find exercise more difficult in this type of environment; there may be a need to increase anti-inflammatory medication during the seasons.

- wearing a scarf or cold air mask warms and humidifies the air before it reaches the airways. Minimize exercising in cold, dry air. EIB has been shown to be eliminated if exercise is done in warm, moist environments.

6. Adequate Cool-Down

Avoid stopping exercise abruptly. To avoid sudden changes in the airway temperature, a warm-down period of 10 minutes is suggested. This warm-down period, however, may need to be longer.

7. Avoidance of Certain Foods

Avoiding certain foods several hours prior to strenuous exercise may be important for some people. The following foods may increase EIB, and in some cases cause anaphylaxis:

Signs include:

7. Chiropractic Care

Consult a licensed practitioner and go through a trial of chiropractic care. Locate a licensed practitioner {find_doctor} here.

Exercise-induced anaphylaxis

This is a rare but frightening and potentially fatal physical allergy. Food ingestion before vigorous activity has been associated with exercise-induced anaphylaxis; exercise-induced anaphylaxis occurs more commonly in hot, humid weather conditions and may also be related to severity of exertion. The teacher should be aware of emergency treatment for this.

Other Suggestions:

Students should exercise for as long as the rest of the class, or until coughing, wheezing or chest tightness develops, which may range from a few minutes to the full lesson. Exercise tolerance will vary greatly among students with asthma, and even from day to day in the same student. Should a student become wheezy or have difficulty breathing during exercise and develop an asthma episode, implement emergency treatment.

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