Neural tube defects (NTDs) occur in approximately six out of every 10,000 live births in the United States annually. NTI)s are serious birth defects involving the brain or spinal cord that can result in infant mortality or serious disability. Because the neural tube forms and closes early on in the pregnancy, the defect can occur before a woman is aware she is pregnant. Adequate folate in healthful diets may reduce a woman's risk of having a child with a brain or spinal cord birth defect. As part of a healthy diet, the daily value for folic acid intake is 400 mcg. daily. Folate intake should not exceed 250% of the DV (1000 mcg).*